In a large bowl, gently combine the ground beef with Cajun seasoning, garlic powder, onion powder, salt, and pepper.

Shape the mixture into four equal patties with a slight indentation in the center.

Preheat grill to medium-high or heat a skillet over medium heat.

Cook patties for 4-5 minutes on one side, flipping only once; add cheese in the last minute.

Toast the buns by spreading butter inside and grilling until golden.

Assemble burgers by spreading spicy mayo on the bottom bun, adding the cheesy patty and toppings.

Let the burgers rest for 3-5 minutes before serving.