In a large bowl, combine the ground beef, Jack Daniels whiskey, Worcestershire sauce, garlic powder, onion powder, black pepper, and salt. Mix gently until just combined; do not overwork the meat.
Divide the mixture into four equal portions and shape them into patties, making a slight indentation in the center of each patty to prevent puffing during cooking.
Preheat your grill or skillet over medium-high heat. Cook the patties for about 4-5 minutes on one side.
Flip the burgers and place a slice of cheddar cheese on each patty. Cook for an additional 4-5 minutes, or until the cheese is melted and the burgers reach your desired doneness.
Toast the hamburger buns on the grill or in a toaster until golden brown.
Assemble the burgers by placing each patty on a bun and adding lettuce, tomato, onion, and a drizzle of BBQ sauce if desired.
Serve immediately and enjoy!