In a large bowl, combine buttermilk, garlic powder, onion powder, paprika, salt, and black pepper. Add the chicken breasts, ensuring they are fully submerged. Cover and refrigerate for at least 1 hour, or up to overnight for best flavor.
Preheat your oven to 400°F. Line a baking sheet with parchment paper.
In a shallow dish, mix together the flour, panko breadcrumbs, grated Parmesan cheese, and dried Italian herbs.
Remove the chicken from the buttermilk marinade, allowing excess to drip off. Dredge each piece in the flour mixture, pressing gently to adhere. Place the coated chicken on the prepared baking sheet.
Bake the chicken for 20-25 minutes, or until golden brown and cooked through (internal temperature should reach 165°F). Flip halfway through for even crispiness.
While the chicken is baking, prepare the sandwich rolls by toasting them lightly in a skillet or toaster.
Once the chicken is done, let it rest for a few minutes before slicing.
To assemble the sandwiches, spread Caesar dressing on the bottom half of each roll. Layer with chopped romaine lettuce, sliced crispy chicken, and additional Parmesan cheese. Top with the other half of the roll.
Serve immediately with lemon wedges on the side for an extra burst of flavor.