Name: Delicious Spinach and Artichoke Chicken Casserole Made Easy
Prep time: 20 min
Cook time: 35 min
Total time: 65 min
Ingredients: 3 cups cooked chicken (shredded or diced, leftover chicken works great); 1 cup artichoke hearts (drained and chopped); 10 ounces frozen spinach (well-drained); 1 cup sour cream (can swap with Greek yogurt); 1/2 cup mayonnaise (optional swap for Greek yogurt); 2 cups mozzarella cheese (divided); 1/2 cup Parmesan cheese (for topping); 1 teaspoon garlic powder; 1 teaspoon onion powder; 1 teaspoon black pepper (to taste); 1 teaspoon salt (to taste); 1 tablespoon olive oil (for greasing the dish); 1 cup breadcrumbs (can be gluten-free); 4 tablespoons butter (melted)

There’s something magical about gathering around a bubbling casserole dish that feels just like home. My Creamy Spinach and Artichoke Chicken Casserole is a comforting dish that not only ticks the boxes for flavor but also offers a beginner-friendly experience for those of us who enjoy cooking homemade meals. With tender chicken and vibrant artichoke hearts mingling in a creamy, satisfying sauce, this casserole is versatile enough for any occasion—from cozy family dinners to delightful potlucks. Plus, you can easily make it ahead of time, so dinner is a breeze, and it’s even lightened up with Greek yogurt for a healthier twist. Ready to embrace this culinary hug? Let’s dive into the delicious details!

Why Will You Love This Casserole?

Comforting, A warm bowl of this Spinach and Artichoke Chicken Casserole wraps you in a cozy embrace with its creamy goodness.

Easy to Prepare: Perfect for beginners, this dish ensures culinary success without any stress.

Versatile Options: Customize ingredients to suit dietary needs—try gluten-free breadcrumbs or swap in Greek yogurt for a lighter version!

Make Ahead: Enjoy the convenience of prepping ahead, allowing flavors to meld beautifully.

Crowd-Pleaser: Bring it to potlucks or family gatherings; it’s sure to impress everyone, pairing wonderfully with a crisp green salad or even some warm garlic bread.

Treat yourself to a delicious homemade experience, and don’t forget to check out the Buffalo Chicken Mac for another delightful casserole option!

Spinach and Artichoke Chicken Casserole Ingredients

Here’s everything you need to create your own Spinach and Artichoke Chicken Casserole!

For the Casserole

Cooked Chicken – Provides a tender protein base; ensure it’s shredded or diced for even distribution. Leftover chicken works great.
Artichoke Hearts – Adds a subtle nutty flavor; drained and chopped to avoid excess moisture.
Frozen Spinach – Nutrient-rich and vibrant; well-drained to prevent a watery casserole.
Sour Cream – Adds richness and balances the sauces; can be swapped with Greek yogurt for a lighter option.
Mayonnaise – Contributes creaminess; optional swap for Greek yogurt.
Mozzarella Cheese – Offers gooey stretchiness; used in the filling and as a topping to achieve a bubbly crust.
Parmesan Cheese – Adds sharpness and helps form a crunchy crust when sprinkled on top.
Garlic Powder – Enhances flavor without the need for fresh garlic.
Onion Powder – Contributes sweetness and complexity to the overall taste.
Black Pepper & Salt – Essential for seasoning; adjust to taste.
Olive Oil – Used for greasing the baking dish to prevent sticking.

For the Crunchy Topping

Breadcrumbs – Creates a crunchy topping; can be substituted with gluten-free options.
Butter – Mixed with breadcrumbs for a golden, rich finish.

Gather these ingredients and get ready to indulge in a comforting Spinach and Artichoke Chicken Casserole that everyone will love!

Step‑by‑Step Instructions for Spinach and Artichoke Chicken Casserole

Step 1: Preheat the Oven
Begin your culinary journey by preheating your oven to 375°F (190°C). This step ensures that your Spinach and Artichoke Chicken Casserole has the perfect environment to bake evenly, developing that delicious golden crust on top. While the oven warms up, gather your ingredients to make the preparation seamless.

Step 2: Combine the Ingredients
In a large mixing bowl, combine the cooked chicken, chopped artichoke hearts, and well-drained frozen spinach. Use a spatula to mix them well, ensuring even distribution. This stage is crucial, as these ingredients are the heart of your casserole. The mixture should appear vibrant and ready to be enveloped in creaminess.

Step 3: Add the Creamy Mixture
Next, introduce the richness by mixing in sour cream, mayonnaise (or Greek yogurt if you prefer), along with mozzarella, Parmesan, garlic powder, onion powder, black pepper, and salt. Stir thoroughly for about 2-3 minutes until all ingredients are evenly blended and the mixture is thick and creamy, ready for its role in this comforting casserole.

Step 4: Prepare the Baking Dish
Lightly grease a 9×13-inch baking dish with olive oil to prevent sticking. This step ensures that your Spinach and Artichoke Chicken Casserole will slide right out when it’s time to serve. The coating should shine gently, indicating it’s ready for your delicious filling.

Step 5: Spread the Mixture
Carefully spread the creamy chicken mixture evenly into the prepared baking dish. Use a spatula to smooth it out, reaching all corners. This even layer will bake beautifully, ensuring each bite is packed with flavor. The mixture should sit about evenly flat, ready to accept the beautiful crunchy topping.

Step 6: Create the Crunchy Topping
In a separate bowl, combine breadcrumbs and melted butter, mixing until the crumbs are well-coated. Sprinkle this crunchy mixture evenly over the prepared casserole, ensuring every corner is covered. This topping will caramelize nicely in the oven, creating a delightful contrast to the creamy base.

Step 7: Add Extra Cheese
Sprinkle any remaining mozzarella and Parmesan cheese over the breadcrumbs for an extra cheesy finish. This layer not only enhances flavor but also contributes to that beautiful bubbly crust that everyone loves. A generous sprinkling ensures a gooey, melty experience with every hearty scoop.

Step 8: Bake the Casserole
Cover the dish tightly with aluminum foil and place it in the preheated oven. Bake for 20 minutes to allow the flavors to meld beautifully. After this time, carefully remove the foil to reveal your casserole and bake uncovered for an additional 10-15 minutes until it’s golden and bubbly, inviting everyone to the table.

Step 9: Cool and Serve
Once beautifully baked, remove the casserole from the oven and let it cool slightly for about 5-10 minutes. This resting period helps the casserole set, making it easier to slice into servings. When ready, dish out the creamy Spinach and Artichoke Chicken Casserole and watch the smiles bloom around your gathering.

Expert Tips for Spinach and Artichoke Chicken Casserole

Drain Thoroughly: Always ensure spinach is well-drained; excess moisture can turn your casserole into a soggy mess instead of a creamy delight.
Customize Flavors: Feeling adventurous? Add red pepper flakes or diced jalapeños for a spicy kick that elevates your Spinach and Artichoke Chicken Casserole.
Prep Ahead: This dish shines when made ahead. Assemble it the night before, cover, and simply pop it in the oven when you’re ready to bake.
Grease the Dish: Never skip greasing your baking dish with olive oil; it prevents sticking and ensures easy serving of your delicious casserole.
Crunchy Topping: For an extra crunch, mix some crushed nuts into your breadcrumb topping—this adds flavor and texture!

How to Store and Freeze Spinach and Artichoke Chicken Casserole

Fridge: Store leftovers in an airtight container for up to 3 days. Reheat in the microwave or oven until warmed through, ensuring the creamy texture is preserved.

Freezer: For longer storage, freeze the casserole before baking. Wrap it tightly in plastic wrap and foil for up to 3 months. Thaw overnight in the fridge before baking.

Make Ahead: Assemble your Spinach and Artichoke Chicken Casserole a day in advance, cover, and refrigerate. Bake directly from the fridge, adding 5-10 minutes to the cooking time.

Reheating: When reheating, cover with foil to prevent the topping from burning, and bake at 350°F (175°C) until heated through. This keeps your dish moist and delicious!

Make Ahead Options

These Spinach and Artichoke Chicken Casserole is a fantastic option for meal prep enthusiasts! You can assemble the casserole up to 24 hours in advance by combining all the ingredients and storing it covered in the refrigerator. To maintain its delicious quality, ensure the spinach is well-drained to prevent excess moisture. When you’re ready to enjoy this comforting dish, simply bake it straight from the fridge, adding an extra 5-10 minutes to the baking time. This simple strategy allows the flavors to meld beautifully, making it just as delicious and ready to impress your family or guests! Enjoy hassle-free dinners with this make-ahead recipe in your back pocket!

What to Serve with Spinach and Artichoke Chicken Casserole

The perfect meal needs just the right companions to shine alongside it, creating a symphony of flavors that elevate your dining experience.

Garlic Bread: The warm, crusty texture perfectly complements the creamy casserole, soaking up those delicious flavors.
Caesar Salad: Crisp romaine tossed in tangy dressing provides a refreshing crunch that enhances the richness of the casserole.
Roasted Vegetables: A colorful medley of seasonal veggies adds a delightful caramelized flavor, bringing balance to your plate.
Quinoa Pilaf: Fluffy and nutty, quinoa serves as a wholesome base that pairs beautifully with the creamy sauce and chicken.
Creamy Coleslaw: The crunch and slight tang of coleslaw offer a delightful contrast, balancing out the casserole’s softness.
Sweet Potato Mash: This naturally sweet side enriches the meal with its earthiness, while its silky texture complements the casserole.
White Wine: A chilled glass of Sauvignon Blanc provides bright acidity that cuts through the richness, enhancing each bite.
Apple Crisp: End on a sweet note with warm apple crisp. Its comforting flavors resonate wonderfully with the homey casserole.
Herb Infused Rice: Light and fragrant, this rice adds an aromatic touch that harmonizes with the casserole’s bold flavors.

Spinach and Artichoke Chicken Casserole Variations

Feel free to get creative and make this delightful casserole your own with these easy swaps and additions!

Greek Yogurt: Substitute Greek yogurt for sour cream or mayonnaise for a lighter, high-protein version without losing creaminess.
Gluten-Free: Use gluten-free breadcrumbs to suit dietary restrictions while still achieving that lovely crunchy topping.
Cheese Swap: Try using sharp cheddar or pepper jack cheese to add a bold flavor twist to the classic recipe; cheese lovers will rejoice!
Add Veggies: Throw in diced bell peppers or mushrooms for an extra crunch and flavor profile—more veggies make it even better!
Spicy Kick: Elevate your casserole by adding chopped jalapeños or a dash of cayenne pepper for a zesty heat that will delight your taste buds.
Herb Infusion: Experiment with adding fresh herbs like parsley or basil for a burst of freshness that elevates the entire dish.
Creamy Spin: Mix in a splash of heavy cream for an ultra-creamy texture that’s perfect for special occasions or when you want to indulge.
Savory Crunch: Mix some crushed walnuts or pecans into your breadcrumb topping for a nutty crunch that pairs delightfully with the creamy filling.

Whichever variation you choose, this casserole will always be a hit—and if you’re looking for more comfort food inspiration, don’t forget to check out the Honey Pepper Chicken or the delectable Chicken Bacon Casserole! Happy cooking!

Spinach and Artichoke Chicken Casserole Recipe FAQs

How do I choose the right artichoke hearts for the casserole?
Absolutely! When selecting artichoke hearts, look for tender, well-drained options—canned or frozen are both good choices. If using canned, check the label and choose those packed in water or brine without excessive additives. Always drain and chop them before use to avoid excess moisture in the casserole.

How should I store leftovers of the Spinach and Artichoke Chicken Casserole?
Very good question! Store any leftovers in an airtight container in the refrigerator for up to 3 days. When reheating, it’s best to place the casserole in the oven at 350°F (175°C) for an even warm-up, ensuring a creamy texture remains intact.

Can I freeze the Spinach and Artichoke Chicken Casserole?
Yes, you can! To freeze, prepare the casserole but do not bake it. Wrap it tightly in plastic wrap and then foil, ensuring there are no air pockets, and freeze for up to 3 months. When ready to bake, thaw it overnight in the refrigerator and bake as directed, adding an additional 5-10 minutes to cooking time if it’s still a bit cold.

What if my casserole is too watery? How can I fix that?
If you find your Spinach and Artichoke Chicken Casserole is watery, it often means that the spinach wasn’t drained sufficiently. To fix a runny mixture, you can try adding more breadcrumbs to help absorb moisture or consider baking it uncovered for a longer period to allow the excess liquid to evaporate. For future preparations, always thoroughly squeeze out excess water from your spinach before combining it with other ingredients.

Can I customize this recipe for dietary restrictions?
Absolutely! This casserole is versatile. To make it gluten-free, simply use gluten-free breadcrumbs instead of regular ones. You can also substitute Greek yogurt for the mayonnaise and sour cream to lighten the dish while maintaining creaminess. If anyone has allergies, checking labels on all store-bought ingredients is a great step to ensure safety.

Is this casserole suitable for pets?
As much as we love our furry friends, it’s best to avoid sharing this Spinach and Artichoke Chicken Casserole with pets. The ingredients like onion powder and garlic powder can be harmful to dogs and cats. Always stick to pet-specific food for your furry companions!